This commissioned draft paper was prepared by Courtney Nelson for the Board on Science and Technology for International Development, National Academy of Sciences. It is based largely on secondary source material and interviews with several key participants in some of the programs described. A final version of the paper will be prepared as an annex to the Academy’s Study of U.S. Capacity to Address Tropical Disease Problems.


I.     Introduction                                                                                          p. 1

II.   The Cholera Story

A.   Origin and Nature of the Disease

B.    American Interest in the Disease

C.   Why Thailand?

D.   The SEATO Center

E.    The Seventh Pandemic and the U.S. Response                                   p. 2

F.    PSCRL to CRL to ICDDR / B                                                            

G.   Bearing of the Cholera Story on our Theme

III. Collaborative Programs                                                                            p. 3

A.   Overview: Framework for Comparisons

B.    The Department of Defense Overseas Laboratories                              p. 3

C.   The Gorgas Memorial Laboratory, Panama                                           p. 4

D.   ICMRT / ICMR / ICIDR                                                                     p. 5

E.    The International Center for Diarrheal Disease Research in Bangladesh     p. 6

F.    Foundation-Supported and International Grant Programs                       p. 7

1.    The Great Neglected Disease Program of the Rockefeller Foundation

2.    The Schistosomiasis Research Program of the Edna McConnell Clark Foundation

3.    The Molecular Biology Program of the MacArthur Foundation

4.    The UNDP/World Bank/WHO Special Program for Research and Training in Tropical Diseases                                                                 p. 8

5.    Comparative Comments

G.   The Smallpox Eradication Campaign                                                  p. 9

IV. Concluding Issues                                                                                  p. 10

V.   Appendix A: Significant Accomplishments of USAMRUs                                   p. 11

VI. Appendix B: Overview of Progress of TDR 1984                                            p. 12

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